See more videos about personalized medicine at Vanderbilt here.
What is PREDICT?
Who is this test for?
Can a DNA test tell anything else?
How will this information be used?
Where can I get information on clinical trials for new drugs?
Prescribing Blood Thinners
Each person responds differently to medicines. Making sure you receive the right medicine at the right dose is one way Vanderbilt offers personalized medicine for you.
In fact, Vanderbilt University Medical Center can now use your genetic information to predict and help prevent bad drug side effects. We call this PREDICT.
What is PREDICT?
PREDICT is a game-changing program at Vanderbilt that applies personalized medicine with automated decision support in real-time – we believe for the first time ever at an academic medical center in the United States.
Background: When heart disease is suspected, patients usually get a cardiac catheterization, an X-ray test that can tell if arteries in the heart are too narrow. If that’s the case, often a small tube called a stent is put inside the troubled artery to keep it open. After that, a drug called Plavix is often prescribed to keep blood from clotting around the stent.
About 25% of heart patients have a genetic variation that makes Plavix less effective for them. The variation prevents the body from effectively processing the drug. In about 3% of people, the variation is very serious, and Plavix doesn’t work at all. In these cases, if a patient is prescribed Plavix, blood clots could form around the stent. That can result in a heart attack or even death.
Process: PREDICT involves taking a blood sample from all patients who get a cardiac catheterization. The sample is tested for the genetic variation related to Plavix, and the results are stored confidentially in the secure electronic medical record and made available when needed. If the patient has the genetic variation that means Plavix may not work, an alert will pop up when his or her doctor tries to order Plavix.
Effects: PREDICT will let the patient’s doctor know ahead of time to prescribe a different drug. We believe this program and others like it will improve safety and save patients’ lives.
Who is this test for?
Right now, only patients in the cardiac catheterization lab are included in the program. As soon as next year, we hope to roll out a similar program for other drugs. The goal will be the same: To tell ahead of time whether a patient will benefit from a drug, and to tailor his or her medical care on an individual level.
Can a DNA test tell anything else?
Yes. Right now, we can test for about 200 genetic variations known to affect many medicines.
How will this information be used?
Currently, the information gathered is used specifically for heart patients who may be prescribed Plavix. In the future, other genetic information will be used to tailor other medication selection and dosing for patients.
Where can I get information on clinical trials for new drugs?
- Visit our clinical trials website for information on trials here at Vanderbilt.
- To find trials that match your qualifications, register on ResearchMatch.
Visit the Vanderbilt Heart website.
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