2023年4月4日 星期二

Acute Effects of Coffee Consumption on Health among Ambulatory Adults


Google翻譯仍有大問題:
Acute Effects of Coffee Consumption on Health among Ambulatory Adults
喝咖啡對臥床成人健康的急性影響
ambulatory translate: (病人)不需臥床的,能走動的,晚上不需留院的

抽象的 錯
背景
咖啡是世界上最常飲用的飲料之一,但飲用咖啡對健康的急性影響仍不確定。

方法

我們進行了一項前瞻性、隨機、病例交叉試驗,以檢查含咖啡因的咖啡對心臟異位搏動和心律失常、每日步數、睡眠時間和血糖水平的影響。 共有 100 名成年人配備了連續記錄心電圖設備、腕戴式加速度計和連續血糖監測儀。 參與者下載了一個智能手機應用程序來收集地理定位數據。 我們使用在 14 天內發送的每日短信來隨機指導參與者飲用含咖啡因的咖啡或避免攝入咖啡因。 主要結果是每日房性早搏的平均次數。 通過使用參與者記錄的實時指標、每日調查、對加蓋日期的咖啡購買收據報銷以及對咖啡店訪問的虛擬監控(地理圍欄)來評估對隨機化分配的依從性。

結果
參與者的平均(±SD)年齡為 39±13 歲; 51% 是女性,51% 是非西班牙裔白人。 對隨機分配的依從性被評估為很高。 攝入含咖啡因的咖啡與每日 58 次心房早搏相關,而在避免攝入咖啡因的日子裡每日發生 53 次心房早搏(率比,1.09;95% 置信區間 [CI],0.98 至 1.20;P=0.10)。 與不攝入咖啡因相比,攝入含咖啡因的咖啡分別與每天 154 次和 102 次室性早搏有關(率比,1.51;95% CI,1.18 至 1.94); 每日步數 10,646 和 9665(平均差,1058;95% CI,441 至 1675); 397 和 432 分鐘的夜間睡眠(平均差異,36;95% CI,25 至 47); 血糖水平分別為 95 mg/dL 和 96 mg/dL(平均差,-0.41;95% CI,-5.42 至 4.60)。

結論
在這項隨機試驗中,與避免攝入咖啡因相比,攝入含咖啡因的咖啡並未導致每日房性早搏明顯增加。 (由加州大學舊金山分校和美國國立衛生研究院資助;CRAVE ClinicalTrials.gov 編號為 NCT03671759。在新選項卡中打開。)





ORIGINAL ARTICLEFREE PREVIEW

Acute Effects of Coffee Consumption on Health among Ambulatory Adults



Abstract

BACKGROUND

Coffee is one of the most commonly consumed beverages in the world, but the acute health effects of coffee consumption remain uncertain.

METHODS

We conducted a prospective, randomized, case-crossover trial to examine the effects of caffeinated coffee on cardiac ectopy and arrhythmias, daily step counts, sleep minutes, and serum glucose levels. A total of 100 adults were fitted with a continuously recording electrocardiogram device, a wrist-worn accelerometer, and a continuous glucose monitor. Participants downloaded a smartphone application to collect geolocation data. We used daily text messages, sent over a period of 14 days, to randomly instruct participants to consume caffeinated coffee or avoid caffeine. The primary outcome was the mean number of daily premature atrial contractions. Adherence to the randomization assignment was assessed with the use of real-time indicators recorded by the participants, daily surveys, reimbursements for date-stamped receipts for coffee purchases, and virtual monitoring (geofencing) of coffee-shop visits.

RESULTS

The mean (±SD) age of the participants was 39±13 years; 51% were women, and 51% were non-Hispanic White. Adherence to the random assignments was assessed to be high. The consumption of caffeinated coffee was associated with 58 daily premature atrial contractions as compared with 53 daily events on days when caffeine was avoided (rate ratio, 1.09; 95% confidence interval [CI], 0.98 to 1.20; P=0.10). The consumption of caffeinated coffee as compared with no caffeine consumption was associated with 154 and 102 daily premature ventricular contractions, respectively (rate ratio, 1.51; 95% CI, 1.18 to 1.94); 10,646 and 9665 daily steps (mean difference, 1058; 95% CI, 441 to 1675); 397 and 432 minutes of nightly sleep (mean difference, 36; 95% CI, 25 to 47); and serum glucose levels of 95 mg per deciliter and 96 mg per deciliter (mean difference, −0.41; 95% CI, −5.42 to 4.60).

CONCLUSIONS

In this randomized trial, the consumption of caffeinated coffee did not result in significantly more daily premature atrial contractions than the avoidance of caffeine. (Funded by the University of California, San Francisco, and the National Institutes of Health; CRAVE ClinicalTrials.gov number, NCT03671759. opens in new tab.)



咖啡對心髒的影響可能和你想的不一樣
新研究發現,咖啡不會對心房收縮產生影響,但可能會在其他方面影響健康。
Julie Wernau2023年4月4日




咖啡愛好者們,提起精神!研究人員稱,美國人最喜歡的「興奮劑」或許不會對心臟健康產生那麼大的風險,但還是有可能在其他方面對健康造成影響。

根據《新英格蘭醫學雜誌》(New England Journal of Medicine)上周三登載的一項新研究,對於最常見的心律失常,咖啡的攝入並不會增加與其風險上升相關的異常心跳。研究人員對100名沒有潛在心臟疾病的人進行了研究,在兩周時間裡監測了他們的心臟、活動以及睡眠狀況。他們發現,喝咖啡的人與不喝咖啡的人,二者在心臟病方面的關鍵風險標記物大致相同。不規則心率——又稱房顫——會導致出現危險血塊,從而引發中風和心衰。

「常見的心律不齊又稱房顫,它並非由咖啡因引起,也不會因它而變得嚴重,儘管許多醫生和患者中廣泛流傳著一種看法,認為這種情況下應避免攝入咖啡。」紐約西奈山心臟中心(Mount...