千年藥方殺菌力......A new (old) cure for MRSA? Revolting recipe from the Dark Ages may be key to defeat infection

Resistance to antibiotic treatments has been increasing around the world. To tackle this problem, scientists at Nottingham University have been testing a medieval Anglo-Saxon remedy for eye infections as reports the BBC's Tom Feilden http://bbc.in/1O5NPYwhttp://bbc.in/1GZsdgj 英國千年藥方竟然有效，殺菌力可比萬古黴素 作者 藍 弋丰 | 發布日期 2015 年 04 月 10 日 | 分類 科技趣聞 , 醫療科技

金黃色葡萄球菌是環境中很常見的菌種，大約有三分之一人口身上都帶有它，平時是正常菌叢，一旦有機會入侵，就會造成各種化膿性炎症，在抗生素發明後，一度不構成威脅，然而，隨著抗生素濫用，金黃色葡萄球菌對許多常用抗生素產生抗藥性，甚至同時對多種抗生素有抗藥性，也就是所謂的多重抗藥性菌株 MRSA（Multiple-resistant Staphylococcus aureus），成為醫療上的重大危機，不過，一本超過千年之久歷史的老古董醫書上記載的藥方，竟然能有效對付它。

A new (old) cure for MRSA? Revolting recipe from the Dark Ages may be key to defeat infection








Scientists have been 'dumbfounded' at the infection-killing ability of the ancient 10th Century cure, after a series of tests in Britain and the US during the past year
JONATHAN OWEN



Monday 30 March 2015

A stomach-churning potion from the Dark Ages could be the death of the modern day Methicillin-resistant Staphylococcus aureus (MRSA) infection, according to researchers who claim that the ancient treatment outperforms conventional antibiotics.

Scientists have been “dumbfounded” at the killing ability of the potion - an ancient cure for eye infections dating back to the 10th Century - after a series of tests in Britain and the US during the past year.

That the Anglo-Saxon recipe, which includes wine, garlic, and bile from a cow’s stomach, could hold the key to defeating MRSA came about after a chance discussion between experts at the University of Nottingham last year.

During a meeting of academics interested in infectious diseases, Dr Christina Lee, an expert in Old English, told microbiologists about Bald’s Leechbook – an Anglo-Saxon medical textbook kept in the British Library which contains remedies for treating infections and other ailments.

Dr Christina Lee, left, and Dr Andrea Clarke from the British Library

Dr Lee translated a recipe for treating styes – an infection of an eyelash usually caused by Staphylococcus aureus - and the past year has seen researchers painstakingly recreate it and test it on MRSA.

The thousand-year-old remedy has proven to be an “incredibly potent” antibiotic, according to lead researcher Dr Freya Harrison, a microbiologist from the University of Nottingham.

The individual ingredients alone did not have any measurable effect but when combined according to the ancient text, they killed up to 90 per cent of MRSA bacteria in infected mice. And in infections grown in the laboratory, only about one bacterial cell in a thousand survived.

“I still can’t quite believe how well this one thousand year old antibiotic actually seems to be working, when we got the first results we were just utterly dumbfounded. We did not see this coming at all,” commented Dr Harrison.

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The findings will be presented at the Society for General Microbiology’s annual conference in Birmingham tomorrow [Weds] and will be submitted to the global science journal, Nature, shortly.

“Modern research into disease can benefit from past responses and knowledge, which is largely contained in non-scientific writings. But the potential of these texts to contribute to addressing the challenges cannot be understood without the combined expertise of both the arts and science,” commented Dr Lee. 

Dr Kendra Rumbaugh, a microbiologist at Texas Tech University who was part of the research team, commented: “These types of wound infections are very difficult to treat, and given that most of the agents we have previously tested displayed little to no efficacy, I was quite skeptical. However, this ‘ancient’ solution performed better than the current ‘gold standard’ (vancomycin) and killed more than 90% of the MRSA in the wounds.”

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Bald’s Leechbook is an Anglo-Saxon medical textbook kept in the British Library

And this is just the start. For the initial success of the research is prompting scientists to look at nine other recipes from the Anglo-Saxon book.

Responding to the news last night, Professor Laura Piddock, director, Antibiotic Action, said: “It is fascinating that this medieval medicine is able to inhibit the growth of MRSA. Investigation of other old anti-infective remedies may facilitate the discovery of antibiotics that could be turned into treatments for use in the 21st century.” 

And Dr Maureen Baker, chair, Royal College of GPs, said: “This fascinating study shows that some of the answers are already out there, and have been used effectively in the past – but looking back and discovering these lost potential treatments will take just as much skill and expertise as developing new ones from scratch. This isn’t going to happen overnight, and will need substantial investment.”

She added: “In the meantime, we need to continue to do what we can, including maintaining excellent hygiene standards, to help stop the spread of superbugs.”

Recipe to treat a stye, translated from Bald’s Leechbook.

“Work and eye salve for a wen, take cropleek and garlic, of both equal quantities, pound them well together, take wine and bullocks gall, of both equal quantities, mix with a leek, put this then into a brazen vessel, let it stand nine days in the brass vessel, wring out through a cloth and clear it well, put it into a horn, and about night time apply with a feather to the eye; the best leechdom.”