2020年7月12日 星期日

Satoshi Ōmura: 阿維菌素以化學修飾的形式伊維菌素,被證明可有效抵抗河盲症和像皮病






Wishing a happy birthday to Satoshi Ōmura!
Ōmura was awarded the 2015 Nobel Prize in Physiology or Medicine for discovering a novel therapy against infections caused by roundworm parasites.
A number of serious infectious diseases are caused by parasites spread by insects. River blindness is caused by a tiny worm that can infect the cornea and cause blindness. Lymphatic filariasis, or elephantiasis, is also caused by a worm and produces chronic swelling. Satoshi Ōmura cultured bacteria, which produce substances that inhibit the growth of other microorganisms. In 1978 he succeeded in culturing a strain from which William Campbell purified a substance, avermectin, which in a chemically modified form, ivermectin, proved effective against river blindness and elephantiasis.

Ōmura因發現一種針對round蟲寄生蟲感染的新穎療法而榮獲2015年諾貝爾生理學或醫學獎。
許多嚴重的傳染病是由昆蟲傳播的寄生蟲引起的。 河盲症是由微小的蠕蟲引起的,該蠕蟲可以感染角膜並導致盲目性。 淋巴絲蟲病或像皮病也由蠕蟲引起,並導致慢性腫脹。 中村聰(Satoshi Ōmura)培養的細菌會產生抑制其他微生物生長的物質。 1978年,他成功地培養出一種菌株,威廉·坎貝爾(William Campbell)從該菌株中純化了一種阿維菌素,該物質以化學修飾的形式伊維菌素,被證明可有效抵抗河盲症和像皮病。






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