ORIGINAL ARTICLEFREE PREVIEW
Acute Effects of Coffee Consumption on Health among Ambulatory Adults
Abstract
BACKGROUND
Coffee is one of the most commonly consumed beverages in the world, but the acute health effects of coffee consumption remain uncertain.
METHODS
We conducted a prospective, randomized, case-crossover trial to examine the effects of caffeinated coffee on cardiac ectopy and arrhythmias, daily step counts, sleep minutes, and serum glucose levels. A total of 100 adults were fitted with a continuously recording electrocardiogram device, a wrist-worn accelerometer, and a continuous glucose monitor. Participants downloaded a smartphone application to collect geolocation data. We used daily text messages, sent over a period of 14 days, to randomly instruct participants to consume caffeinated coffee or avoid caffeine. The primary outcome was the mean number of daily premature atrial contractions. Adherence to the randomization assignment was assessed with the use of real-time indicators recorded by the participants, daily surveys, reimbursements for date-stamped receipts for coffee purchases, and virtual monitoring (geofencing) of coffee-shop visits.
RESULTS
The mean (±SD) age of the participants was 39±13 years; 51% were women, and 51% were non-Hispanic White. Adherence to the random assignments was assessed to be high. The consumption of caffeinated coffee was associated with 58 daily premature atrial contractions as compared with 53 daily events on days when caffeine was avoided (rate ratio, 1.09; 95% confidence interval [CI], 0.98 to 1.20; P=0.10). The consumption of caffeinated coffee as compared with no caffeine consumption was associated with 154 and 102 daily premature ventricular contractions, respectively (rate ratio, 1.51; 95% CI, 1.18 to 1.94); 10,646 and 9665 daily steps (mean difference, 1058; 95% CI, 441 to 1675); 397 and 432 minutes of nightly sleep (mean difference, 36; 95% CI, 25 to 47); and serum glucose levels of 95 mg per deciliter and 96 mg per deciliter (mean difference, −0.41; 95% CI, −5.42 to 4.60).
CONCLUSIONS
In this randomized trial, the consumption of caffeinated coffee did not result in significantly more daily premature atrial contractions than the avoidance of caffeine. (Funded by the University of California, San Francisco, and the National Institutes of Health; CRAVE ClinicalTrials.gov number, NCT03671759.)
咖啡對心髒的影響可能和你想的不一樣
新研究發現,咖啡不會對心房收縮產生影響,但可能會在其他方面影響健康。
Julie Wernau2023年4月4日
咖啡愛好者們,提起精神!研究人員稱,美國人最喜歡的「興奮劑」或許不會對心臟健康產生那麼大的風險,但還是有可能在其他方面對健康造成影響。
根據《新英格蘭醫學雜誌》(New England Journal of Medicine)上周三登載的一項新研究,對於最常見的心律失常,咖啡的攝入並不會增加與其風險上升相關的異常心跳。研究人員對100名沒有潛在心臟疾病的人進行了研究,在兩周時間裡監測了他們的心臟、活動以及睡眠狀況。他們發現,喝咖啡的人與不喝咖啡的人,二者在心臟病方面的關鍵風險標記物大致相同。不規則心率——又稱房顫——會導致出現危險血塊,從而引發中風和心衰。
「常見的心律不齊又稱房顫,它並非由咖啡因引起,也不會因它而變得嚴重,儘管許多醫生和患者中廣泛流傳著一種看法,認為這種情況下應避免攝入咖啡。」紐約西奈山心臟中心(Mount...